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[1]何一鸣,赵泽宇,贺超恒,等.素蛋白/姜黄素药膜的体外降解性能研究[J].丝绸,2018,55(11):111103.[doi:10.3969/j.issn.1001-7003.2018.11.003]
 HE Yiminga,ZHAO Zeyuab,et al.(51603140)( BK20150372)(GZ1094)(2017M620223)(SYG201638) (1997)2014tcligang@suda.edu.cn In vitro degradation of silk fibroin/curcumin drug-loaded membranes[J].Journal of Silk,2018,55(11):111103.[doi:10.3969/j.issn.1001-7003.2018.11.003]
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素蛋白/姜黄素药膜的体外降解性能研究(PDF)
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《丝绸》[ISSN:1001-7003/CN:33-1122/TS]

卷:
55
期数:
2018年11期
页码:
111103
栏目:
研究与技术
出版日期:
2018-11-20

文章信息/Info

Title:
(51603140)( BK20150372)(GZ1094)(2017M620223)(SYG201638) (1997)2014tcligang@suda.edu.cn In vitro degradation of silk fibroin/curcumin drug-loaded membranes
文章编号:
1001-7003(2018)11-0011-07
作者:
何一鸣赵泽宇贺超恒谢旭升樊珊佩陈国强李 翼李 刚
1.苏州大学 a.纺织与服装工程学院;b.现代丝绸国家工程实验室,江苏 苏州 215123; 2.南京大学 南京大学化学化工学院 南京 210093; 3.曼切斯特大学 材料学院曼切斯特 M13 9PL 英国
Author(s):
HE Yiming1a 2 ZHAO Zeyu1ab HE Chaoheng1abXIE Xueshen1ab FAN Shanpei1a CHEN Guoqiang1ab LI Yi3 LI Gang1ab
1a.College of Textile and Clothing Engineering; 1b.National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China; 2.School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China; 3.School of Materials, The University of Manchester, Manchester M13 9PL, UK
关键词:
肠道支架丝素蛋白姜黄素药膜体外降解
Keywords:
intestinal tract stent silk fibroin curcumin drug membrane In vitro degradation
分类号:
R318.08
doi:
10.3969/j.issn.1001-7003.2018.11.003
文献标志码:
A
摘要:
为了有效缓解结直肠癌引起的梗阻,在前期研制的覆膜生物可降解支架的基础上,对支架外层药膜的降解性能进行了研究。通过对三种不同药物浓度的药膜体外降解后的质量损失、降解液pH值变化、力学性能、二级结构、表面形貌以及药膜的药物缓释性能进行分析,研究其降解情况和影响因素。结果表明,三组药膜的降解速度相近,均在15降解完成,药膜变成碎片状,质量损失达60%,药膜的silk I 构型受到破坏。药膜中的药物释放率高,可达(83.29±2.45) %。因此,该载药支架药膜在置入人体后可能在规定时间内完成降解并进行药物释放。
Abstract:
To effectively relieve obstruction caused by colorectal cancer, the biodegradation property of drug membrane at the outer layer of the stent was studied based on biodegradable stent developed. The degradation and influencing factors were investigated through analyzing mass loss of drug membrane with three different concentrations after in vitro degradation, pH changes of degradation solution, mechanical properties, secondary structure, morphology, and drug sustained release property of drug membrane. The results showed that the three groups of drug membranes had the similar degradation performance generally. Degradation behaviors were observed within 15 days, and drug membrane became shredded membrane. The mass loss reached 60%, and silk I configuration was damaged. The membranes had high drug release rate, as high as (83.29±2.45) %. Therefore, such drug membrane can complete degradation and release the drug within the specified time after implantation in the human body.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(51603140);江苏省自然科学青年基金( BK20150372);国际中德科学基金研究项目(GZ1094);中国博士后科学基金(2017M620223);苏州市科技计划重点产业技术创新项目(SYG201638)
收稿日期:2018-04-09
修回日期:2018-00-00
作者简介:何一鸣(1997—),男,2014级纺织工程专业本科生
通讯作者:李刚,副教授,tcligang@suda.edu.cn
更新日期/Last Update: 2018-10-15