|本期目录/Table of Contents|

[1]刘 凯,匡大江,王诗怡,等.蚕丝蛋白用作胶囊壳材料的研究[J].丝绸,2018,55(12):121102.
 LIU Kaia,KUANG Dajianga,WANG Shiyia,et al.(BK20171239)(15KJA540001) (1994)lushenzhou@suda.edu.cn Study on silk protein used as capsule shell material[J].Journal of Silk,2018,55(12):121102.
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蚕丝蛋白用作胶囊壳材料的研究(PDF)
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《丝绸》[ISSN:1001-7003/CN:33-1122/TS]

卷:
55
期数:
2018年12期
页码:
121102
栏目:
研究与技术
出版日期:
2018-12-20

文章信息/Info

Title:
(BK20171239)(15KJA540001) (1994)lushenzhou@suda.edu.cn Study on silk protein used as capsule shell material
文章编号:
1001-7003(2018)00-0000-00
作者:
刘 凯匡大江王诗怡付 华王垠龙卢神州
苏州大学 a.纺织与服装工程学院;b.现代丝绸国家工程实验室,苏州 215123
Author(s):
LIU Kaia KUANG Dajianga WANG Shiyia FU Huaa WANG Yinlonga LU Shenzhou*ab
 a.College of Textile and Clothing Engineering; b. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China
关键词:
丝素丝胶胶囊崩解细胞相容性
Keywords:
silk fibroin sericin capsule disintegration cytocompatibility
分类号:
TB383
doi:
-
文献标志码:
A
摘要:
文采用蚕丝蛋白来替代明胶,研究不同配比丝素丝胶制备的胶囊壳复合材料的结构特性。通过加入脯氨酸、甲酰胺、乙二醇来调节材料在模拟胃液、肠液中的崩解时间,通过细胞培养检测材料的细胞相容性等。结果表明,随着丝胶含量的提高,复合材料容易在胃液中崩解,而随着丝素含量提高,材料不易在胃液浸泡下崩解,但肠液崩解。利用结构调节剂可以期望获得某些用于胃、肠胶囊壳的新型材料。
Abstract:
At present, the main raw material for capsule production on the market is gelatin. Since gelatin capsules are expensive and have the disadvantage of low solubility which causes that the drug effect cannot be effectively exerted. Thus, it is imperative to find alternative materials. In this paper, silk fibroin (SF) was used as a substitute for gelatin, and structural properties of capsule shell composites prepared with different ratio of silk fibroin and sericin were studied. The disintegration time of the material in the simulated gastric juice and intestinal fluid was adjusted by adding proline, formamide, and ethylene glycol, and the cell compatibility of the material was detected by cell culture. The results showed that with the increase of sericin content, the material was easy to disintegrate in gastric juice. With the increase of silk fibroin content, the material was not easy to disintegrate in gastric juice immersion, but disintegrated in intestinal juice. Some new materials for the production of gastro-intestinal capsule shells can be expected to be obtained by using structural regulators

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备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金项目(BK20171239);江苏省高校自然科学研究重大项目(15KJA540001)
收稿日期:2018-04-17
修回日期:2018-00-00
作者简介:刘凯(1994—),男,硕士研究生,研究方向为丝蛋白生物材料
作者:卢神州,教授,lushenzhou@suda.edu.cn
更新日期/Last Update: 2018-11-07